Isolated Raised GGT


This guideline applies to adults over 18 years.


Key Features of Assessment

(In patients > 80 years oldor with significant frailty use clinical  to avoid unnecessary investigation)


In addition to usual assessment check for:

  • Diabetes,
  • Excessive alcohol or recreational drug use
  • Pregnancy
  • Medications– esp. statins, anticonvulsants, antibiotics (particularly flucloxacillin, erythromycin, doxycycline or co-amoxiclav), paracetamol.
  • Herbal treatments




Consider causes and further investigations depending on the type of abnormality:



  1. Consider causes as below
  2. If unexplained repeat LFTS + GGT in 1-3 months.
  3. If still elevated, consider liver USS.


Advice and Guidance

Please send advice and guidance requests via e-RS to: http://rms.cornwall.nhs.uk/primary_care_clinical_referral_criteria/rms/primary_care_clinical_referral_criteria/gastro/rcht_hepatology_advice_and_guidance




If GGT persistently elevated in isolation with no known cause refer for Hepatology advice and guidance.


For East-facing Cornwall practices. Please see South & West Devon DRSS Referral Guidelines



Supporting Information

For professionals:


For patients:




Page Review Information


Review date

April 2024

Next review date

April 2026


Speciality Lead GP


Dr Madeleine Attridge (Hepatology lead GP)







Dr Hyder Hussaini (Consultant Hepatologist RCHT)

Anna Barton (Principal Clinical Biochemist)