Login

Primary Immunodeficiency (PID)


Introduction

PID disorders are inherited conditions sometimes caused by single-gene mutations, or more often by an unknown genetic susceptibility combined with environmental factors1.

 

In Scope  

Patients suspected of having Primary Immunodeficiency (PID)

 

Not in scope    

Secondary or ‘acquired’ Immunodeficiency. e.g. HIV, malnutrition, immunodeficiency secondary to chemotherapy*

*this list is not exhaustive.


 

Referral Criteria

  • Adults or children with unusually frequent or severe infections, or infections with unusual organisms. For further information see Immunodeficiency UK website. Secondary causes should be excluded (e.g. drugs, underlying malignancy, structural defects)

 

Referral Instructions

  • Referrals for PID are via referral letter in the usual way. (The Allergy referral form cannot be used)
     
  • Please include the following in your referral
     
  • Results of any microbiology (e.g. sputum/swabs)
     
  • Full immunisation history (vaccine names and date administered)
     
  • Relevant Radiology (if done outside Derriford)
     
  • Details of family history (especially infections)
     
  • FBC (with differential, immunoglobulin levels (if bacterial infections), sputum cultures. If history strongly suggested of immunodeficiency, referral should not be delayed pending blood results
     
  • If history suggestive of hereditary angioedema (angioedema, no urticaria, often involving recurrent abdominal pain, family history) check C4 and follow advice on angioedema RMS page.

 

Supporting Information

Patients

  1. The basics - Immunodeficiency UK
  2. Symptoms & diagnosis - Immunodeficiency UK

 

Professionals      

  1. Immunodeficiency (Primary and Secondary) | Doctor
  2. https://www.immunodeficiencyuk.org/wp-content/uploads/2021/05/GuideforGPs.pdf
  3. Symptoms & diagnosis - Immunodeficiency UK

 

References

  1. Immunodeficiency | British Society for Immunology

 

Page Review Information

Review Date            03 June 2025               

Next Review Date    03 June 2027        

Speciality Lead GP  Dr Kate Northridge

Contributors             Dr Catherine Elliott, Specialist Doctor in Allergy, University Hospital Plymouth