Primary Immunodeficiency (PID)
- Known primary humoral (antibody), cell mediated and innate immune defects
- Adults or children with unusually frequent or severe infections, or infections with unusual organisms. Secondary causes should be excluded (eg drugs, underlying malignancy, structural defects)
- Additional information required: Results of microbiology (eg sputum/swabs), full immunisation history (vaccine names and date administered). Radiology (if done outside Derriford). Details of family history (especially infections)
- If history strongly suggestive of immunodeficiency referral should not be delayed pending blood results, however useful investigations include FBC with differential, immunoglobulin levels (if recurrent bacterial infections), sputum cultures.
- If history suggestive of hereditary angioedema (angioedema, no urticaria, often involving recurrent abdominal pain, family history) check C4 and if low referral to PID clinic. If strongly suggestive history and normal C4, referral to PID clinic appropriate. Otherwise treat as for spontaneous angioedema.
Review Date 13/8/2019
Next Review Date 13/8/2020
Author Dr Andrew Whyte, Consultant Allergist and Immunologist, Derriford Hospital
GP Sifter Dr Isabel Boyd
Version No. 1.1