Lymphadenopathy occurs in a range of infective and neoplastic conditions and may be isolated, involving a single node or nodes within an anatomical grouping, or generalised.

Isolated lymphadenopathy frequently results from local infection or neoplasia.


Suspicions of lymphoma should be heightened by the presence of generalised or progressive lymphadenopathy, hepatosplenomegaly or accompanying ‘B’ symptoms (>10% weight loss in 6 months, soaking sweats, unexplained fevers).


Referral pathways:


Appropriate investigation in primary care for patients not meeting criteria for urgent referral:

FBC with a blood film

Glandular fever screen

Consider CXR



NICE Guideline: Suspected cancer: recognition and referral, NG12 (2015) http://www.nice.org.uk/guidance/ng12



Dr Adam Forbes, Consultant Haematologist, RCHT

Dr Bridgitte Wesson, GP & Kernow RMS Haematology guideline lead


Review date: 11/12/2020

Next Review due: 11/12/2021