Common causes include:

  • Infection

Eg. Sepsis, salmonella, Brucella

Epstein Barr, CMV, influenza

HIV testing should be offered for any unexplained neutropenia

  • Drug induced

Eg. Antithyroid medications, macrolides, procainamides, clozapine, sulphasalazine

  • Autoimmune disease and Chronic Inflammatory Disease

Eg. Rheumatoid, Sjogren’s

  • Nutritional deficiency

Eg. folate, B12, copper

  • Bone marrow pathology

Eg. Leukaemia, myelodysplasia, lymphoma, aplastic anaemia


Rarer causes include congenital.

The normal range is lower for those of African ethnic descent.






Useful reference article: https://bestpractice.bmj.com/topics/en-gb/893



Dr Richard Noble, Consultant Haematologist, RCHT

Dr Bridgitte Wesson, GP & Kernow RMS Haematology guideline lead


Review date: 05/08/2020

Next Review 05/08/2021